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ea0099p353 | Reproductive and Developmental Endocrinology | ECE2024

Renal 11β-hydroxysteroid dehydrogenase type 2 is of central importance for 11-oxygenated androgen biosynthesis and is disrupted in chronic kidney disease

Tomkins Maria , McDonnell Tara , Cussen Leanne , S Sagmeister Michael , Oestlund Imken , Shaheen Fozia , Harper Lorraine , S Hardy Rowan , E Taylor Angela , C Gilligan Lorna , Arlt Wiebke , McIlroy Marie , de Freitas Declan , Conlon Peter , Magee Colm , Denton Mark , O'Seaghdha Conall , Snoep Jacky , Heinz-Storbeck Karl , Sherlock Mark , W O'Reilly Michael

11-oxygenated androgens are a group of adrenal-derived C19 steroids that require activation in peripheral tissues. 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) has been shown in vitro to be essential for 11-oxygenated androgen activation, converting 11β-hydroxyandrostenedione (11OHA4) to 11-ketoandrostenedione (11KA4), the direct precursor of the potent androgen 11-ketotestosterone (11KT). As the kidney is the major site of HSD11B2 expression, we hypoth...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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